Some цитокины are absolutely necessary

Some цитокины are absolutely necessary. Агонист ИЛ-1 completely blocks implantation. However this experience is difficult for reproducing. Necessity of two molecules in the course of implantation is absolutely precisely proved: parent LIF and ИЛ-11. There is a hypothesis, that some cases of barreness obscure генеза and habitual невынашивания are connected with absence of production LIF (Leukemia Inhibitory Factor) эндометрием or its quantitative deficiency. This hypothesis is already almost proved, as work in which the difference of production LIF in culture эндометриального эксплантата fruitless and фертильных women is studied is spent. Nevertheless, it is very difficult phenomenon as there are 3 isoforms LIF of various activity. It can explain partly barreness at women "good, but not enough active manufacturers LIF" and on the contrary. And, at last, easy degree of a mutation of molecule LIF is proved at some kinds of barreness. As to ИЛ-11 blockade of its receptors completely blocks implantation.