At the further continuation inflammatory

At the further continuation of inflammatory reaction, and also at some kinds of a pathology, such as the endometriosis etc., is absent return to normal "толерогенности", there comes "defective implantation" and spontaneous abortion after biochemical pregnancy. These spontaneous abortions are caused not only cages by T-killers, but also development of the inflammatory process caused by cages CD4 +. Other mechanism influencing processes of implantation, - reaction fas/fas-ligand. Really, activated cages Т (CD3 +) экспрессируют a fas-protein. Possible reaction of a fas-protein with fas-ligandom leads to death of a cage through апоптоз. Now it is impossible to be limited to concept Тh1, секретирующих TNF and gamma interferon, against Th2, producing ИЛ-3, ИЛ-4, ИЛ-10 [2] as last years the role of others цитокинов in децидуальной to a cover and a placenta is established, that it is difficult to contain in the classical scheme of mutual relations Тh1 and Th2. For example, important role ИЛ-12 and ИЛ-18 is underlined. Surplus синергистов ИЛ-18 + ИЛ-12 leads to an abortion that allows to carry them to group цитокинов, synthesised Тh1. Really, higher level ИЛ-18 in group with habitual невынашивавием, than in control group is observed.