For last years has occurred big

For last years there was a considerable quantity of the important changes in structure and application the COOK: decrease in a daily dose эстрогенного a component almost in 2 times, transition from высокодозированных the combined contraceptives to low - and to the microdosed out preparations, introduction in preparations new гестагенов. Perfection прогестинов was realised at the expense of increase of their contraceptive activity and reduction of undesirable by-effects caused by them. It has allowed to reconsider indications and contra-indications to application the COOK and to define their acceptability. Now choice preparations are the COOK of the third generation with the minimum effective dose of components entering into them and containing гестагены new type (гестоден, дезогестрел, норгестимат, диеногест), not possessing андрогенными and metabolic effects. It has raised their safety and therapeutic action on an organism of the woman.